Taş Yasdanup Toprak Döşenenler: Kandiye Kuşatması Örneğinde Osmanlı Askerlerinin Metristeki Mücadele ve Yaşamı (1667-1669)

Dmd065623 1661..1669

In this study, IC50 shift and time-dependent inhibition (TDI) experimentswere carried out tomeasure the ability of amiodarone (AMIO), and its circulating human metabolites, to reversibly and irreversibly inhibit CYP1A2, CYP2C9, CYP2D6, and CYP3A4 activities in human liver microsomes. The [I]u/Ki,u values were calculated and used to predict in vivo AMIO drug-drug interactions (DDIs) for pharmace...

Op-brai150094 1667..1678

Optimal phase alignment between oscillatory neural circuits is hypothesized to optimize information flow and enhance system performance. This theory is known as communication-through-coherence. The basal ganglia motor circuit exhibits exaggerated oscillatory and coherent activity patterns in Parkinson’s disease. Such activity patterns are linked to compromised motor system performance as evince...

Pathogenesis of renal calculi Renal taş hastalığı patogenezi

Taş hastalığının, kemik, böbrek ve barsaklar arasında etkileşimi içeren poligenik ve çok faktörlü karakterine bağlı olarak taş oluşumu karışık bir süreçtir. Son yıllarda böbrek taşı oluşumuna yol açan tam sürecin belirlenmesi için önemli gelişmeler elde edilmiş olmasına karşın, taş oluşumu patogenezine ilişkin halen çok sayıda cevaplanmamış soru bulunmaktadır. Farklı taş fenotipleri bulunmaktad...

Remembering the Good Old Days: the Ottoman Nasihatname [Advice Letters] Literature of the 17th Century

This study analyses the Ottoman Nasihatname [Advice Letters] literature of the 17th century. This tradition had its roots mainly in the so-called mirror writers of the 10th century. The chapter explores the atmosphere which allowed mirror writers to produce their work. After outlining the peculiar features of this literature and its influence on the Ottomans, it concentrates on some of the text...

Robert Hooke's Micrographia of 1665 and 1667.